Monday, July 18, 2011

NEW GENOME STUDIES SHOW THAT AFRICAN AND NON-AFRICAN POPULATIONS INTERMIXED WELL AFTER MIGRATION OUT OF AFRICA 60,000 YEARS AGO

Researchers have probed deeper into human evolution by developing an elegant new technique to analyze whole genomes from different populations. One key finding from the Wellcome Trust Sanger Institute's study is that African and non-African populations continued to exchange genetic material well after migration out-of-Africa 60,000 years ago. This shows that interbreeding between these groups continued long after the original exodus.

For the first time genomic archaeologists are able to infer population size and history using single genomes, a technique that makes fewer assumptions than existing methods, allowing for more detailed insights. It provides a fresh view of the history of humankind from 10,000 to one million years ago.

"Using this algorithm, we were able to provide new insights into our human history," says Dr Richard Durbin, joint head of Human Genetics and leader of the Genome Informatics Group at the Sanger Institute. "First, we see an apparent increase in effective human population numbers around the time that modern humans arose in Africa over 100,000 years ago.

"Second, when we look at non-African individuals from Europe and East Asia, we see a shared history of a dramatic reduction in population, or bottleneck, starting about 60,000 years ago, as others have also observed. But unlike previous studies we also see evidence for continuing genetic exchange with African populations for tens of thousands of years after the initial out-of-Africa bottleneck until 20,000 to 40,000 years ago.

"Previous methods to explore these questions using genetic data have looked at a subset of the human genome. Our new approach uses the whole sequence of single individuals, and relies on fewer assumptions. Using such techniques we will be able to capitalize on the revolution in genome sequencing and analysis from projects such as The 1000 Genomes Project, and, as more people are sequenced, build a progressively finer detail picture of human genetic history."

The team sequenced and compared four male genomes: one each from China, Europe, Korea and West Africa respectively. The researchers found that, although the African and non-African populations might have started to differentiate as early as 100,000 to 120,000 years ago, they largely remained as one population until approximately 60,000 to 80,000 years ago.

Following this the European and East Asian ancestors went through a period where their effective population size crashed to approximately one-tenth of its earlier size, overlapping the period when modern human fossils and artifacts start to appear across Europe and Asia. But, for at least the first 20,000 years of this period, it appears that the out-of-Africa and African populations were not genetically separated. A possible explanation could be that new emigrants from Africa continued to join the out-of-Africa populations long after the original exodus.

"The novel statistical method we developed is computationally efficient and doesn't make restrictive assumptions about the way that population size changed. Although not inconsistent with previous results, these findings allow new types of historical events to be explored, leading to new observations about the history of mankind." The researchers believe that this technique can be developed further to enable even more fine-grained discoveries by sequencing multiple genomes from different populations. In addition, beyond human history, there is also the potential to investigate the population size history of other species for which a single genome sequence has been obtained.

http://www.sciencedaily.com/releases/2011/07/110713131419.htm

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